Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect Biomater. Sci., 2014

China, India anisomelic acid (terpenoid), ovatodiolide (terpenoid),. 4,7- oxycycloanisomelic acid. (terpenoid). Anopterus spp. (Evergreen shrub). Escalloniaceae.

The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- and duration-dependent manner. Acridine Orange & Ethidium Bromide (AO & EB) and Hoechst 33258 WO2014033366A1 PCT/FI2013/050828 FI2013050828W WO2014033366A1 WO 2014033366 A1 WO2014033366 A1 WO 2014033366A1 FI 2013050828 W FI2013050828 W FI 2013050828W WO 2014033366 A1 WO201 Anisomelic acid (AA) (Fig. S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica 7 , which we have previously shown to be cytotoxic to oral and ANISOMELIC-ACID Plant -- -- Wealth of India. Activities (1) ACE-Inhibitor 20 ug (weak activity) BETULINIC-ACID Plant -- 100.0 -0.63 Pavannasasivam, G., & M.U.S.

Ovatodiolide & anisomelic acid, two diterpenoid lactones from Anisomeles malabarica R.br @inproceedings{Purushothaman1975OvatodiolideA, title={Ovatodiolide & anisomelic acid, two diterpenoid lactones from Anisomeles malabarica R.br}, author={K. K. Purushothaman and B. Bhima-Rao and K. Kalyani}, year={1975} } In a pioneering study, we showed that a naturally occurring compound (anisomelic acid), as well as synthetic derivatives that we have developed based on this compound, effectively degrade the HPV E6 and E7 oncoproteins, i.e., the carcinogenic proteins in the virus that are known to play a key role in promoting the devel opment of HVP-positive cancers, says cell biology professor John Eriksson 2019-05-23 Preethy C.P., et al., 2013, “Analysis of the cytotoxic potential of anisomelic acid isolated from Anisomeles malabarica,” Scientia pharmaceutica; 81(2): 559-566. [ Web Reference ] Singh I., et al., 2010, “Anticonvulsant potential of Anisomeles malabarica leaves against experimentally induced convulsions in rats,” International Journal of Green Pharmacy; 4(3): 199-205. Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species.

ANISOMELIC-ACID Plant -- -- Wealth of India. Activities (1) ACE-Inhibitor 20 ug (weak activity) BETULINIC-ACID Plant -- 100.0 -0.63 Pavannasasivam, G., & M.U.S. Sultanbawa. 1974. Betulinic acid in the Dilleniaceae and a review of its natural distribution. Phytochem. 13:2002-2006. Activities (22) Anthelmintic AntiHIV EC50=2.0 ug/ml Kashiwada, Y

The herb is used as an astringent and carminative. It is used in folk medicine in the treatment of diverse conditions such as inflammatory skin diseases, Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Rajendran Senthilkumar1, Yury Brusentsev2, Preethy Paul1, Fang Cheng1, Maria Sippola-Thiele1, Patrik Eklund2 and John E Eriksson1 1Turku Centre of Biotechnology, Finland 2Abo Akademi University, Finland Targeted delivery of a new anticancer compound Anisomelic acid using chitosan-coated porous silica nanorods for an enhanced apoptotic effect in vitro by Rajendran Senthilkumar a, Didem Şen Karamanb, Preethy Paula, Emma M. Björkc, Magnus Odénc, John E. Eriksson*,a and Jessica M. Rosenholm*,b Preethy C.P., et al., 2013, “Analysis of the cytotoxic potential of anisomelic acid isolated from Anisomeles malabarica,” Scientia pharmaceutica; 81(2): 559-566. [ Web Reference ] Singh I., et al., 2010, “Anticonvulsant potential of Anisomeles malabarica leaves against experimentally induced convulsions in rats,” International Journal of Green Pharmacy; 4(3): 199-205.

Pharmaceutical compositions of anisomelic acid and their use Download PDF pharmaceutical composition: cells: antiviral: apoptosis: anisomelic acid; Prior art

19 Feb 2018 acetoxy malabaric acid and anisomelol are isolated as macrocyclic diterpenes, while anisomelic acid, ovatodlolide are as diterpenoid lactones, 19 Dec 2013 Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic 8 Jul 2014 acid activates the PKR pathway and induces apoptosis through diterpenoid anisomelic acid causes depletion of E6 and E7 viral. 20 Jan 2009 Mohammad A. Akbarsha, Sakari Hietanen, John E. Eriksson, Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 24 Jun 2019 amines, acid anhydride and carboxylic compounds. Characterization revealed the presence of phyto compound such as aniso melic acid, 22 May 2019 as anisomelic acid, anisomeloide, ovatodiolide, 2-acetoxymalabaric acid, anisomelyl acetate anisomelin, betulinic acid, citral, gerainic acid, 24 Nov 2017 Novel action modality of the diterpenoid anisomelic acid causes depletion · of E6 and E7 viral oncoproteins in HPV-transformed cervical Aldrich-331562; Cyclohexanepentanoic acid 0.98; CAS No.: 5962-88-9; Synonyms: 5-Cyclohexylvaleric acid; Linear Formula: C6H11(CH2)4CO2H; Empirical 30 Jul 2018 Title: Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas. Yury Brusentsev, Abo may be due to the presence of volatile compounds such as anisomelic acid, betulinic acid, citral, gerainic acid and ovatodiolide in the plant extract (Guha Bakshi Pharmaceutical compositions of anisomelic acid and their use Download PDF pharmaceutical composition: cells: antiviral: apoptosis: anisomelic acid; Prior art Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas. R Senthilkumar, Yury Brusentsev, Preethy Paul, Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect. Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect. Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas.

Phytochem. 13:2002-2006. Activities (22) Anthelmintic AntiHIV EC50=2.0 ug/ml Kashiwada, Y Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species.
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Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Annual Congress on Medicinal Chemistry, Pharmacology and toxicology July 30 - 31 , 2018 Amsterdam , Netherlands. Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Fang Cheng, Maria Sippola-Thiele, Patrik Eklund and John E Eriksson. Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells.

Here, we describe the molecular interactions of AA with two serum proteins, human serum albumin (HSA) and bovine serum albumin (BSA Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles mal - abarica . Recently, we have studied the mode of action of AA-mediated apoptosis Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Annual Congress on Medicinal Chemistry, Pharmacology and toxicology July 30 - 31 , 2018 Amsterdam , Netherlands. Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Fang Cheng, Maria Sippola-Thiele, Patrik Eklund and John E Eriksson Our earlier research on the cembranoid, anisomelic acid (AA) showed that, AA has the potential to induce apoptosis in HPV cells by the depletion of E6 and E7 oncoproteins. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a co-solvents or surfactant or a combination thereof.
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Paul P, Kumar Rajendran S, Peuhu E, Alshatwi AA, Mohammad AA, Hietanen S, and Eriksson JE (2014): Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. Biochemical Pharmacology. 89:171–184.

In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica particles (Chitosan-NR-MSP). diterpenoids – 4, 7 – oxycyclo anisomelic acid, 4 – methylene – 5 – hydroxy ovatodiolide (I), 4 – methylene – 5 – oxo anisomelic acid. The herb is used as an astringent and carminative. It is used in folk medicine in the treatment of diverse conditions such as inflammatory skin diseases, Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Rajendran Senthilkumar1, Yury Brusentsev2, Preethy Paul1, Fang Cheng1, Maria Sippola-Thiele1, Patrik Eklund2 and John E Eriksson1 1Turku Centre of Biotechnology, Finland 2Abo Akademi University, Finland Targeted delivery of a new anticancer compound Anisomelic acid using chitosan-coated porous silica nanorods for an enhanced apoptotic effect in vitro by Rajendran Senthilkumar a, Didem Şen Karamanb, Preethy Paula, Emma M. Björkc, Magnus Odénc, John E. Eriksson*,a and Jessica M. Rosenholm*,b Preethy C.P., et al., 2013, “Analysis of the cytotoxic potential of anisomelic acid isolated from Anisomeles malabarica,” Scientia pharmaceutica; 81(2): 559-566. [ Web Reference ] Singh I., et al., 2010, “Anticonvulsant potential of Anisomeles malabarica leaves against experimentally induced convulsions in rats,” International Journal of Green Pharmacy; 4(3): 199-205. Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect By Rajendran Senthilkumar, Didem Şen Karaman, Preethy Paul, Emma M. Björk, Magnus Odén, John E. Eriksson and Jessica M. Rosenholm petroleum ether extract of plant contains a triterpenic acid known as betulinic acid [3] while the hexane extract consists of β-sitosterol and diterpenoids (ovatodiolide and anisomelic acid) [4].

Pharmaceutical compositions of anisomelic acid and their use Download PDF pharmaceutical composition: cells: antiviral: apoptosis: anisomelic acid; Prior art

Paul P, Kumar Rajendran S*, Peuhu E*, Alshatwi AA, Mohammad AA, Hietanen S, and Eriksson JE (2014): Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. Biochemical Pharmacology. 89:171–184.

Paul P, Kumar Rajendran S, Peuhu E, Alshatwi AA, Mohammad AA, Hietanen S, and Eriksson JE (2014): Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. Biochemical Pharmacology. 89:171–184.